dupilumab conjunctivitis treatment

Investigators identified 20 cases of. Key clinical point.

A A Man Aged 46 Years 6 Weeks After Starting Dupilumab Marked Download Scientific Diagram

Patients with atopic dermatitis AD who initiated dupilumab were at a 2-fold higher risk of developing conjunctivitis within 6 months of treatment initiation vs.

. Volume 17 Issue 5 May 2019. Purpose To describe three cases of bilateral cicatrizing conjunctivitis associated with dupilumab treatment for atopic dermatitis. 1 While considered a safe long-term medication for the treatment of these conditions dupilumab has been associated with conjunctivitis of varying severity.

A number of treatment protocols for conjunctivitis in dupilumab-treated patients with AD have been proposed in the literature including warm compresses artificial tears eyedrops or ointments with antihistamines anti-inflammatories corticosteroid drops and ointments anti-infective therapies calcineurin inhibitors topical cyclosporine A and. Long-term safety data beyond one year is still being collected. Dupilumab binds to the alpha-chain of the interleukin IL-4 receptor thus inhibiting signaling of IL-4 and IL-13.

Very few patients stopped taking the medication due to side effects. In all of the clinical trials analyzed patients receiving dupilumab had a significant increase in conjunctivitis 86 to 221 vs the placebo group 21 to 111. Treatment options include topical corticosteroids and topical calcineurin inhibitors.

The present review highlights the clinical presentation of dupilumab-associated. Despite this the pathogenesis of conjunctivitis in dupilumab-treated patients is not well-understood and no standard guidelines exist on how to diagnose and treat this particular clinical condition. Treatments included antifungal corticosteroid cream itraconazole tablets and tacrolimus 01 ointment.

While the rate of adverse events on dupilumab is generally low mild-to-moderate conjunctivitis associated with redness as well as a burning and foreign body sensation has been reported in up to 28 of patients. Treatment options include topical corticosteroids and topical calcineurin inhibitors. BLA 761055S-042 Dupixent dupilumab injection 4 Version date.

Further patients with more severe baseline AD are more likely to develop conjunctivitis and other ocular complications according to the study. Those who initiated other systemic therapies with comorbid asthma further increasing the risk. The present review highlights the clinical presentation of dupilumab-associated conjunctivitis and addresses pharmacological and non-pharmacological options available for the treatment of this clinically highly relevant condition.

However researchers noted that patients who receive. This is usually mild and usually treated without. All received a prescription of trehalosehyaluroate tear substitute to hydrate conjunctival mucosa.

While conjunctivitis was a significant adverse event occurring in 3 to 14 of patients with atopic dermatitis AD who received biweekly dupilumab treatments in phase 3 trials vs. One in 15 patients who start dupilumab treatment may develop conjunctivitis during the first 6 months most of which is manageable with ophthalmic treatments results from large study of US. Up to 1 in 5 people taking dupilumab develop conjunctivitis which can cause itching redness and dryness of the eye.

Dupilumab is a new drug and we are continuing to learn about its potential and adverse effects. Treatment was efficacious and safe in all AD phenotypesparticularly in diffuse eczemawith just more than 20 of patients reporting adverse events AEsconjunctivitis 108 flushing 36 followed by injection-site reaction fatigue. At baseline 9 75 of the 12 patients had severe AD.

October 12 2018 Reference ID. The conjunctivitis occurred at a mean of 158 weeks of treatment range 8-41 weeks and was considered severe or moderate-to-severe in 4 patients. Trial evidence of more than 1500 people shows that dupilumab is a well-tolerated treatment.

The mean age at conjunctivitis onset was 30 years. Dupilumab was stopped in 3 patients all of whom had severe conjunctivitis. Several therapeutic approaches were successfully used in clinical practice for treatment of mild conjunctivitis without discontinuation of dupilumab including hyaluronic.

Conjunctivitis a predisposition to keratoconus and anterior subcapsular cataracts are considered minor criteria of AD. Observations Case 1 is a 69 year-old male with a history of mild. Dupilumab may cause conjunctivitis.

Glaucoma cataracts posterior subscapular and and infectious keratoconjunctivitis may complicate therapy with corticosteroids. Dupilumab is the first biologic approved for use in treatment of moderate to severe atopic dermatitis AD 1 2 3 4 5. About 4 years after dupilumabs approval were interested in how conjunctivitis has played out in our daily clinical practice lead study investigator Maria C.

Dupilumab targets interleukin IL-4.

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A A Man Aged 46 Years 6 Weeks After Starting Dupilumab Marked Download Scientific Diagram